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CID 4109 Model-Independent Dynamic Contrast Analysis Parameters (Current)
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## CID 4109 Model-Independent Dynamic Contrast Analysis Parameters

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Type:

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Version:

  20150916

UID:

  1.2.840.10008.6.1.994

Table CID 4109. Model-Independent Dynamic Contrast Analysis Parameters

Coding Scheme Designator | Code Value | Code Meaning | SNOMED-RT ID | UMLS Concept Unique ID | Units
--- | --- | --- | --- | --- | ---
DCM | 126320 | IAUC |  |  | DT (mmol/l.s, UCUM, "mmol/l.s")
DCM | 126321 | IAUC60 |  |  | DT (mmol/l.s, UCUM, "mmol/l.s")
DCM | 126322 | IAUC90 |  |  | DT (mmol/l.s, UCUM, "mmol/l.s")
DCM | 126323 | IAUC180 |  |  | DT (mmol/l.s, UCUM, "mmol/l.s")
DCM | 126324 | IAUCBN |  |  | DT {normalized}, UCUM, "normalized"
DCM | 126325 | IAUC60BN |  |  | DT {/AIF}, UCUM, "/AIF"
DCM | 126326 | IAUC90BN |  |  | DT {/AIF}, UCUM, "/AIF"
DCM | 126327 | IAUC180BN |  |  | DT {/AIF}, UCUM, "/AIF"
DCM | 126370 | Time of Peak Concentration |  |  | DT (s, UCUM, "s")
DCM | 126372 | Time of Leading Half-Peak Concentration |  |  | DT (s, UCUM, "s")
DCM | 126371 | Bolus Arrival Time |  |  | DT (s, UCUM, "s")
DCM | 113069 | Time To Peak |  |  | DT (s, UCUM, "s")
DCM | 126374 | Temporal Derivative Threshold |  |  |
DCM | 126375 | Maximum Slope |  |  |
DCM | 126376 | Maximum Difference |  |  |
DCM | 126377 | Tracer Concentration |  |  | DT (mmol/l, UCUM, "mmol/l")

### Note

(126326, DCM, "IAUC90BN") can be used for DCE-MRI using a Gd-based contrast agent to represent the IAUGCBN measurement in the claim of the QIBA DCE MRI Quantification Profile, though the concept itself is not specific to the modality or the contast agent used. See http://www.rsna.org/QIBA_Protocols_and_Profiles.aspx. See also Ng, CS., et al. "Reproducibility of Perfusion Parameters in Dynamic Contrast-Enhanced MRI of Lung and Liver Tumors: Effect on Estimates of Patient Sample Size in Clinical Trials and on Individual Patient Responses." AJR 194, no. 2 (February 1, 2010): W134-40. http://dx.doi.org/10.2214/AJR.09.3116.

The type of contrast agent and the AIF used for blood normalization may or may not be post-coordinated.

E.g., voxel-wise IAUCBN measurements encoded as a parametric map with the quantity defined by the Quantity Definition Sequence (0040,9220) in a Real World Value Map might be encoded as:

(246205007, SCT, "Quantity") = (126326, DCM, "IAUC90BN")

(370129005, SCT, "Measurement Method") = (126362, DCM, "User-defined AIF ROI")

(123011, DCM, "Contrast Bolus/Agent") = (58281002, SCT, "Gadolinium")

E.g., an IAUCBN measurement for an ROI encoded in a structured report might be encoded as:

NUM (126326, DCM, "IAUC90BN") = 0.230 (UNITS = ({normalized}, UCUM, "normalized")

>HAS CONCEPT MOD: CODE (370129005, SCT, "Measurement Method") = (126364, DCM, "Blind Estimation of AIF")

Note that the generic ROI measurement templates do not have the contrast/bolus agent as a parameter; this may be implicit from context, or inherited from the (121058, DCM,"Procedure reported") in the parent template.

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